L1-adaptive Methods for Control of Patient Response to Anesthesia

In this paper, we discuss the first application of recently developed L1-adaptive control methods for closedloop control of anesthesia delivery during surgery. Our initial objective, described herein, is to design controllers that are robust to inter-patient variability, such that patients follow a prespecified Bispectral Index profile. The controllers are designed from identification-based models constructed from clinical trial data.